crossing boundaries

molecular interactions in malaria

The Alliance Berlin-Canberra addresses fundamental issues in malaria through an International Research Training Program (IRTG 2290). Molecular insights into Plasmodium infections can generate novel evidence-based strategies to develop curative and prophylactic drugs, and immunization strategies that elicit lasting protection against the disease.


The program covers four research areas:

  1. Nutrient Uptake and Metabolism
  2. Parasite Genetics and Adaptations
  3. Immune Responses
  4. Host Genetics and Drug Discovery

All research projects will involve work carried out in both Berlin and Canberra and PhD students will graduate with a dual PhD from both the Humboldt Universität zu Berlin and The Australian National University. PhD students in the program will have the opportunity to participate in a customized training program that includes voluntary internships and that will support students in acquiring critical skills to prepare for increasingly globalized and competitive public and private job markets. The program's language is English.

The IRTG 2290 is a member program of the Graduate School at the
IRI Life Sciences and funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) and The Australian National University (ANU).

Funded by

In collaboration with

The image on our website header depicts the sporozoite stage in the life-cycle of the malaria parasite. This image was kindly provided by Dr. Volker Brinkmann, Head of Microscopy at the Max Planck Institute for Infection Biology, in Berlin.

Upcoming Events


Obituary for Birte Steinhöfel.

It is with great sadness and heavy hearts that the IRTG 2290 and the team Molecular Genetics at HU announce the passing of our treasured friend. Read more here.

Hirst et al. (2022)  Purification of functional Plasmodium falciparum tubulin allows for the identification of parasite-specific microtubule inhibitors. Current Biology

Henkel et al. (2021) Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid biosynthetic pathway. J Biol Chem

van Loon et al(2021) Changing pattern of Plasmodium falciparum multi-drug resistance-1 gene polymorphisms in southern Rwanda. Antimicrob Agents Chemother.

Mukherjee et al(2021) Dual RNA-seq meta-analysis in Plasmodium infection identifies host-parasite interactions. mSystems

Diemer et al(2021) Sperm migration in the genital tract - in silico experiments identify key factors for reproductive success.
PLoS Computational Biology

Fraser et al. (2021) Of Membranes and Malaria: Phospholipid Asymmetry in Plasmodium falciparum-Infected Red Blood Cells’, Cellular and Molecular Life Sciences 


June 15, 2020, 4 p.m.

"Hitchhiking to the next host - The malaria parasite and its carpool"

Francois Korbmacher will give a talk for the "Digital für Natur" series at the Museum für Naturkunde.