Projects


* For ANU-based projects, please note that in addition to admittance to the graduate program you need to apply for a scholarship at the ANU.


Research Area A - Nutrient Uptake and Metabolism

Project A1 - position filled

 

Conserved and Lineage-specific Functions of Plasmodium Membrane Transport Proteins

 

Host Lab: KAI MATUSCHEWSKI (HUB)

Partner Lab: Alexander Maier (ANU)

 

Keywords: Plasmodium, malaria, transporter, virulence attenuation

Keywords (methods): experimental genetics, CRISPR/Cas9, endogenous tagging, fluorescent microscopy, cell culture, Anopheles mosquito work

Project A2- position filled

 

Lipids as targets for antimalarial drugs

 

Host Lab: ALEXANDER MAIER (ANU)

Partner Lab: Kai Matuschewski (HUB) 

 

Keywords: malaria, lipid metabolism, drug-able molecules, enzymes, transporters 

Keywords (methods): reverse genetics, CRISPR/Cas9, endogenous tagging, fluorescent microscopy, cell culture, metabolic modelling

 

Project A3 - position filled

 

TBA

 

Host Lab: EDDA KLIPP (HUB)

Partner Lab: Alex Maier (ANU)

 

Keywords: Development of a mathematical model for lipid metabolism, comparison male vs female lipid composition, effect of chemical perturbations on lipid metabolism

 


Project A5 - position taken

 

Metabolic Characterisation and Chemotherapeutic Targeting of Persistent T. gondii and P. falciparum Parasites

 

Host Lab : MARTIN BLUME (HUB, Robert Koch - Institut)

Partner Lab: Kai Matuschewski (HUB), Kevin Saliba (ANU)

 

Keywords: Toxoplasma gondii, Plasmodium falciparum, antimicrobial resistance, metabolism, untargeted metabolomics, parasite persistence, drug resistance

 

Keywords (methods): untargeted metabolomics techniques, liquid and gas chromatography-coupled mass spectomotry, stabel isotope-resolved flux profiling

Project A6 - position available

 

Role of host lipids in the establishment of the human malaria parasite in the mosquito 

 

Host Lab: ELENA LEVASHINA (MPI)

Partner Lab: Alexander Maier (ANU)

Additional Interaction Partner: Martin Blume (RKI)

 

Keywords: malaria, transmission, lipid metabolism, gametocytes, sexual differentiation, ookinete development

 

Keywords (methods): cell culture, infections in A.gambiae, metabolic labelling, reverse genetics, CRISPR/Cas9, cell biology, mass-spectrometry

 



Research Area B - Parasite Genetics and Adaptions

Project B1 - position filled

 

RNA Processing and Turnover in Apicomplexan Organelles

 

Host Lab: CHRISTIAN SCHMITZ-LINNEWEBER (HUB)

Partner Lab: Melanie Rug, Alex Maier (ANU)

 

Keywords: Mitochondria, RNA processing and turnover, HPR proteins

Project B2

 

'New Permeability Pathway' Structure and Function in Plasmodium falciparum

 

Host Lab: MELANIE RUG (ANU)

Partner Lab: Andreas Herrmann, Thomas Korte (HUB)

 

Keywords: New Permeability  pathway, Plasmodium falciparum, drug target

 

Keywords methods: protein expression, artificial membrane system, cryo electron microscopy

Project B3 - position filled

 

Characterizing Plasmodium Protein Function at the Parasite-Host Interface During both Liver and Blood Infection Stages

 

Host Lab: ALYSSA INGMUNDSON (HUB)

Partner Lab: Melanie Rug, Alexander Maier (ANU)

 

Keywords: parasite-host interactions, liver-stage development, proximity-dependent protein labeling, parasite genetics, correlative light and electron microscopy.


Project B4 - position filled

 

Tubulin - A Novel Lead to Antimalarial Drug Discovery

 

Host Lab: SIMONE REBER (HUB)

Partner Lab: Kevin Saliba (ANU)

 

Keywords: Microtubules, in vitro reconstitution, microtubule-binding agents

Project B5 - position filled

 

Structural Elucidation of the Interaction of Apicoplast-Resident Ferredoxin with its Interacting Proteins

 

Host Lab: FRANK SEEBER (HUB, Robert Koch - Insitut)

Partner Lab: Christina Spry, Kevin Saliba (ANU)

 

Keywords: nanobodies, two-hybrid screening, 3D structure determination, ferredoxin, apicoplast metabolism, protein-protein interaction

Project B6- position available

 

Exploring Species and Stage-Dependent Differences in the Pantothenate Requirement of Malaria Parasite

 

Host Lab: CHRISTINA SPRY, KEVIN SALIBA (ANU)

Partner Lab: Alyssa Ingmundson (HUB), Martin Blume (HUB, RKI)

 

Keywords: Coenzyme A biosynthesis, drug target, salvage, liquid chromatography-mass spectrometry, metabolic labelling

 

 



Research Area C - Immune Responses

Project C1 - position filled

 

Title - t.b.a.

 

Host Lab: LEIF SANDER (HUB, Charité)

Partner Lab: Ian Cockburn (ANU)

 

Keywords: vaccination, clinical experimental research, ex vivo co-culture systems

Project C2- position available

 

Utilization of platelet-derived peptides to explore Plasmodium biology and develop antimalarial drug leads.

 

Host Lab: BRENDAN MCMORRAN (ANU)

Partner Lab: TBA

 

Keywords: platelet factor 4, peptide, Plasmodium falciparum, peptide-molecule conjugate approach

Project C3- position filled

 

Understanding the basis of strain specific protection against malaria.

 

Host Lab: IAN COCKBURN (ANU)

Partner Lab: Leif Sander (HUB, Charité)

 

Keywords: antibodies, cross reactive var genes

 


Project C4 - position filled

 

Determinants of Semi-Immunity and Disease Tolerance in Malaria

 

Host Lab: FLORIAN KURTH (HUB, Charité)

Partner Lab: Ian Cockburn (ANU), LEIF SANDER (HUB, Charité) & CERMEL

 

Keywords: Plasmodium, disease tolerance, bedside-to-bench approach, multiparametric phenotyping

 

Keywords (method): antigen specific T-cell enrichment, CyTOF, ex vivo phagocytosis assays



Research Area D - Host Genetics and Responses

Project D1 - position filled

 

Susceptibility to and Manifestation of Malaria: Role of Iron Deficiency and Polymorphisms of Iron Regulation

 

Host Lab: FRANK MOCKENHAUPT (HUB, Charité)

Partner Lab: TBA

 

Keywords: Iron deficiency, hepcidin, polymorphism

Project D2

 

The Antiplasmodial Activity of Riboflavin Analogues

 

Host Lab: KEVIN SALIBA (ANU)

Partner Lab: Frank Seeber (HUB, Robert Koch - Institut)

 

Keywords: Riboflavin, Antimetabolites, Mechanism of Action, Protein expression, Whole Genome Sequencing, Enzyme Assays.