Parasite Genetics and Adaption - Project B4

Tubulin - S Novel Lead to Antimalarial Drug Discovery

Host lab: Simone Reber (Humboldt-Universität zu Berlin) 

 

Partner labs at ANU: Kevin Saliba, Melanie Rug (Australian National University)

 

Key words: Microtubules, in vitro reconstitution, microtubule-binding agents

 

Methodology: Advanced microscopy, in vitro reconstitution, protein biochemistry, quantitative biology

 

The highly dynamic microtubule cytoskeleton plays an essential role in the structural integrity of malarial parasites. Consistent with its important role, microtubule-disruptive drugs have great potential as anti-malarial agents. The current therapeutic options of microtubule-disruptive drugs, however, are limited by their high toxicity to mammalian cells. The aim of this PhD project is to characterise Plasmodium tubulin biochemically and biophysically in order to improve its druggability and to advance the potential of Plasmodium tubulin as anti-malarial.

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We are looking for highly qualified candidates with a master’s degree in molecular biology, biochemistry, biophysics or equivalent - particularly those experienced in protein biochemistry and/or microscopy and image analysis are invited to apply.

 

Please only apply via our webpage. In case you have any further questions, please e-mail me