Differences in Intrinsic Tubulin Dynamics Properties Contribute to Spindle Length Control in Xenopus Species.
William G. Hirst, Abin Biswas, Kishore K. Mahalingan, Simone Reber
Current Biology 30, 1–7 June 8, 2020
Hirst et al. show that microtubules assembled from tubulins of two closely related frogs, Xenopus laevis and X. tropicalis, display different dynamic instability
parameters in vitro. Computational simulations and spindle assembly assays show that differences in tubulin-dependent microtubule dynamics are sufficient to tune spindle mass and length.