Plasmodium Para-Aminobenzoate Sythesis and Salvage Resolve Avoidance of Folate Competetion and Adaption to Host Diet

 Joachim Michael Matz, Mutsumi Watanabe, Mofolusho Falade, Takayuki Tohge, Rainer Hoefgen, Kai Matuschewski. 2019. Cell Reports 26, Pages 356 - 363


In Brief

Matz et al. present an integrated approach of experimental genetics and nutritional metabolite restriction to demonstrate two complementary folate acquisition strategies of the malaria parasite in the blood: endogenous synthesis and salvage of the folate precursor pABA. Uptake of pABA, and not folate, is physiological, facilitating avoidance of host-parasite competition.